Free guide, updated 2026
How to Clean Titanium Dioxide Off Manufacturing Equipment
For pharmaceutical, nutraceutical, personal care, and cosmetics manufacturers who keep finding white haze on stainless steel after cleaning.
Titanium dioxide does not dissolve and does not rinse away. It spreads. Equipment that looks clean after a wipe-down can still fail visual inspection, trigger a second cleaning cycle, and hold up the next batch. This 18-page guide explains why TiO2 behaves this way and how to remove it the first time.
- Why TiO2 clings to stainless steel, glass-lined vessels, and elastomers
- What the "visually clean" failure costs in re-cleaning, downtime, and quality review
- How to choose a detergent and a cleaning process that work together
Three fields. Submit and the PDF opens right away.
Three things to know before you download
The short version of what the guide covers in detail.
01
It spreads instead of rinsing.
TiO2 is insoluble and extremely fine. A traditional rinse often redistributes the particles across the surface instead of removing them.
02
White haze is a production problem.
Visible residue means re-cleaning, downtime, extra quality review, and delayed batches. In GMP environments it can also mean more documentation before equipment is released.
03
The detergent is half the answer.
Removal depends on particle detachment and suspension. Even the right chemistry leaves haze if the process does not keep TiO2 suspended until it is rinsed away.
.png?width=520&name=2026-Chematic-Titanium-Dioxide-Guide%20(1).png "Cover of the 2026 Dober Chematic guide to cleaning products containing titanium dioxide")
What is inside the guide
- What TiO2 is and where it shows up: coated tablets, sunscreens, lotions, creams, and pigmented products
- What makes it hard to clean: surface charge, insolubility, and agglomeration
- Common cleaning failures, starting with the "visually clean" haze and what it costs
- Keys to success: why you target the entire product residue, not the TiO2 alone
- How to find your solution: contact a specialist, send a sample
- Next steps, including what a Custom Cleaning Evaluation returns
Written for the people who own the cleaning result
QA and validation, process engineers, manufacturing leads, and operators in pharma, biopharma, nutraceutical, personal care, OTC, and cosmetics plants.
When the guide is not enough
Chematic is Dober's line of formulated detergents for regulated cleaning. Chematic 422 is the Chematic detergent commonly used on film coatings, pigments and dyes, titanium dioxide, and iron oxides. When a standard recommendation is not enough, our lab evaluates a sample of your product and returns a written detergent and process recommendation, along with a sample to try.
Request a Custom Cleaning EvaluationRequest a detergent sample
Solving problems like this one since 1957. Prefer to read first? The ungated overview of cleaning titanium dioxide is here.
Get the 2026 titanium dioxide cleaning guide
18 pages. Three form fields. The PDF opens as soon as you submit.